The molecular basis for T-type Ca2+ channel inhibition by G protein beta2 2 subunits
نویسندگان
چکیده
منابع مشابه
Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+/calmodulin-dependent protein kinase II.
Ang II receptor activation increases cytosolic Ca2+ levels to enhance the synthesis and secretion of aldosterone, a recently identified early pathogenic stimulus that adversely influences cardiovascular homeostasis. Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a downstream effector of the Ang II-elicited signaling cascade that serves as a key intracellular Ca2+ sensor to feedback-reg...
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Two-pore-domain K channels provide neuronal background currents that establish resting membrane potential and input resistance; their modulation provides a prevalent mechanism for regulating cellular excitability. The so-called TASK channel subunits (TASK-1 and TASK-3) are widely expressed, and they are robustly inhibited by receptors that signal through G q family proteins. Here, we manipulate...
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We previously reported that the xanthine nucleotide binding Goa mutant, GoaX, inhibited the activation of Gi-coupled receptors. We constructed similar mutations in G11a and G16a and characterized their nucleotide binding and receptor interaction. First, we found that G11aX and G16aX expressed in COS-7 cells bound xanthine 5*-O-(thiotriphosphate) instead of guanosine 5*-O(thiotriphosphate). Seco...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2006
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0603945103